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L7 Chronic Inflammation


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chronic inflammation
inflammation of prolonged duration; concomitant tissue destruction and repair; mononuclear inflammatory cells; fibrosis
innate & adaptive immunity
Unlike acute inflammation, chronic inflammation is the result of both ______ & _______ _______
H. Pylori
example of chronic inflammation due to progression from acute:
chronic cholecystitis
example of chronic inflammation due to recurrent episodes of acute inflammation:
microorganisms
example of chronic inflammation due to persistent infection by certain _____________: TB, leprosy
exposure
examples of chronic inflammation due to prolonged _______ to potentially toxic agents: endogenous e.g. bone, exogenous e.g. asbestos fibres, sutures, alcohol
autoimmunity
example of chronic inflammation due to ___________: Hashimoto's thyroiditis
unknown
The causes of chronic inflammation in Crohn's disease, ulcerative colitis and sarcoidosis are...
anaemia
may result from chronic inflammation if cytokines affect RBC production via bone marrow & kidneys
plasma cells
type of B cells present in chronic inflammation
fibroblasts
responsible for fibrin formation and collagen deposition in granulation tissue
angiogenesis
formation of new blood vessels occurring in granulation tissue
GRANULOMA
Focal collections of inflammatory cells in tissues: macrophages, epithelioid cells (phagocytic cells containing foreign material), giant cells, lymphocytes; T cells are Th1 type (secrete IL2 & IFNy); release of IL-12 by macrophages critical in initiation of response
mononuclear leukocytes
cells that surround granuloma
3
number of layers in noncaseating epthelioid granuloma
4
number of layers in caseating epthelioid granuloma
caseous necrosis
...occurs in the inner ring of an caseating epithelioid granuloma
bacteria
Cause of granulamatous inflammation: eg TB, leprosy, syphilis, cat scratch
parasite
Cause of granulamatous inflammation: eg schistosomiasis
fungus
Cause of granulamatous inflammation: eg Histomplasma, cryptococcus
inorganic metals or dust
Cause of granulamatous inflammation: eg silicosis, berylliosis
foreign body
Cause of granulamatous inflammation: eg Suture, vascular graft
unknown
Cause of granulamatous inflammation: eg sarcoidosis, ulcerative colitis