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Level 25

Antimicrobials (drug use)


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Amoxicillin cover
Gram +ve and Gram -ve
Amoxicillin cover
resistance from staph, 50% of e coli, 15% of h influenzae
Amoxicillin indications
OM, sinusitis, oral infections
Amoxicillin indications
bronchitis, exacerbation of COPD, CAP, h influenzae infections
Amoxicillin indications
invasive salmonellosis, listerial meningitis
Co-amoxiclav cover
Gram +ve and Gram -ve, anti beta-lactamase
Co-amoxiclav indications
resistant strains of staph, e coli, h influenzae
Flucloxacillin indications
penicillin-resistant staphylococci
Piperacillin-tazobactam + gentamicin
severe pseudomonal infections
Cephalosporins cover
Gram +ve and Gram -ve
Cephalosporins indications
septicaemia, pneumonia, meningitis
Cephalosporins indications
biliary tract infections, peritonitis, UTIs
Macrolides cover
Gram +ve and Gram -ve
Macrolides indications
penicillin allergy
Macrolides indications
respiratory infections, whooping cough, Legionnaire's
Macrolides indications
campylobacter enteritis, chlamydia
Tetracyclines cover
Gram +ve and Gram -ve
Tetracyclines indications
respiratory infections, ENT infections
Tetracyclines indications
chlamydia, acne
Fluoroquinolones cover
aerobic Gram +ve and Gram -ve
Fluoroquinolones cover
resistance from anaerobic bacteria
Fluoroquinolones indications
respiratory infections, UTIs, GI infections, bone and joint infections, gonorrhoea
Aminoglycosides cover
Gram +ve and some Gram -ve
Gentamicin cover
resistance from anaerobic bacteria
Gentamicin indications
serious infections: UTIs, intra-abdominal sepsis, sepsis of unknown origin
Gentamicin + amoxicillin + flucloxacillin
infective endocarditis
Metronidazole cover
anaerobic bacteria and some aerobic bacteria
Metronidazole indications
abdominal sepsis, c dif colitis, amoebiasis, giardiasis
Metronidazole indications
bacterial vaginosis, trichomoniasis
Clindamycin cover
Gram +ve cocci, anaerobic bacteria
Clindamycin indications
staph joint and bone infections, intra-abdominal sepsis
Clindamycin indications
penicillin allergy
Clindamycin indications
MRSA infections (second line)
Trimethoprim indications
UTIs, respiratory infections
Trimethoprim indications
prostatitis, shigellosis, invasive salmonella
Nitrofurantoin cover
good against e coli
Nitrofurantoin indications
uncomplicated UTI
Glycopeptides cover
Gram +ve aerobic and anaerobic
Vancomycin indications
MRSA, antibiotic-associated colitis
Vancomycin indications
allergies to beta lactam antimicrobials
isoniazid + rifampicin + pyrazinamide + ethambutol
tuberculosis (2 months of treatment)
isoniazid + rifampicin
tuberculosis (6 months of treatment)
+ corticosteroids
meningeal or pericardial tuberculosis