Level 33
Level 34

Prescribing in kidney disease


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NSAIDs
may cause worsening of renal function
Thiazide diuretics
less effective if GFR < 30
Potassium-sparing diuretics
increased risk of hyperkalaemia if GFR < 30
Atenolol
renally excreted
Bisoprolol
partially renally excreted
Diltiazem
partially renally excreted
Antimicrobials
many drugs need dose reduction in renal disease
Aminoglycoside antibiotics
excretion is dependent on GFR, only use when no alternative
Nitrofurantoin
ineffective if GFR < 60
Digoxin
renally excreted
Lithium
renally excreted, very sensitive to renal impairment
Low molecular weight heparin
renally excreted
Methotrexate
renally excreted