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Level 159

NME MCQs (I)


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Glyceraldehyde 3-phosphate —> 3 phosphoglycerate
Which ONE of the following conversions in glycolysis leads to the most direct production of ATP by substrate-level phosphorylation?
Increased circulating insulin
Which ONE of the following leads to increased glycolysis in the liver?
Glyceraldehyde 3-phosphate + P; —> 1,3-bisphosphoglycerate
Which ONE of the following reactions is shared by glycolysis and gluoconeogenesis?
They are expressed in liver cells
Which of the following statements is true about both hexokinase and glucokinase?
Simple precursor molecules act as substrates for synthesis of more complex molecules
Which of the following is UNIQUELY associated with anabolic processes?
3
How many net molecules of ATP are generated in the conversion of fructose 6-phosphate to two lactates?
requires a dehydrogenase converting NAD* to NADH
The conversion of dihydroxyacetone phosphate to pyruvate:
stimulating the enzymatic activity of an effector protein
The heterotrimeric G proteins that are coupled to a variety of receptors mediate signal transduction by:
The high-energy phosphate group of 1,3-bisphosphoglycerate used to synthesize ATP from ADP is a reversible reaction at normal physiologic conditions
Which ONE of the following statements is CORRECT?
hepatocytes
Hexokinase, phosphofructokinase-1, and pyruvate kinase are the three irreversible enzymes of glycolysis. All three are subject to metabolic regulation in:
Decreased level of ATP
Which ONE of the following intracellular changes is expected to occur in red blood cells severely deficient in pyruvate kinase?
Increased circulating insulin
Which ONE of the following leads to increased glycolysis in the liver?
Lipogenesis from dietary fructose will still progress at a significant rate
A sample of liver tissue taken by biopsy from an infant with recurrent events of hypoglycemia has revealed that triose phosphate isomerase was the only enzyme missing in this tissue. Which ONE of the following descriptions for this individual is CORRECT?
The cycle produces 3 moles of NADH and 1 mole of FADH2 per mole of acetyl CoA oxidized to CO2 and H2O
Which ONE of the following statements concerning the citric acid cycle is CORRECT?
The irreversibility of pyruvate dehydrogenase precludes the formation of pyruvate from acetyl CoA, and explains why glucose cannot be formed from acetyl CoA in gluconeogenesis
Which ONE of the following statements concerning energy metabolism is CORRECT?
requires thiamine pyrophosphate
The conversion of isocitrate to fumarate:
Three ATP
Which ONE of the following most closely describes the number of high-energy phosphate (ATP and GTP) molecules formed when one molecule of succinyl CoA is converted to malate in the citric acid cycle?
A low ratio of NAD*/NADH
Which ONE of the following conditions will decrease the oxidation of acetyl CoA by the citric acid cycle?
the conversion of 1 mole of isocitrate to 1 mole of succinate results in the formation of 5 moles of ATP (including those obtained from oxidative phosphorylation)
The following statement concerning the citric acid cycle is incorrect:
Malate
In which ONE of the following compounds do carbons derived from pyruvate leave mitochondria for the synthesis of glucose during fasting?
fatty acids from glucose
An individual is homozygous for a liver phosphofructokinase-1 that has a dissociation constant (Kd) for fructose 2,6-bisphosphate that is 10 times greater than normal. Relative to the normal individual, this person will have trouble synthesizing:
Pyruvate + CO2; —> oxaloacetate
Which ONE of the following reactions in gluconeogenesis requires biotin as a factor?
Fructose 1,6-bisphosphate —> fructose 6-phosphate
Which ONE of the following reactions is unique to gluconeogenesis?
involves a CO2-dependent carboxylation
The synthesis of glucose from pyruvate by gluconeogenesis:
biotin is required
In the conversion of pyruvate to glucose during gluconeogenesis:
requires the participation of biotin
The synthesis of glucose from pyruvate by gluconeogenesis:
lactate production increases
Production of glucose by gluconeogenesis in the liver is inhibited by ingestion of ethanol because:
Impaired conversion of amino acids to glucose
A 13-year-old female was brought to your office by her mother. who was troubled by her daughter's ‘ chronic fatigue. dizziness. and loss of weight. The patient was 5 feet 5 inches tall and weighed 103
1 mole of fructose 6-phosphate
Which ONE of the following precursors (on a molar basis) yields the most glucose?
Oxaloacetate —> phosphoenolpyruvate
Which ONE of the following reactions is catalyzed by an enzyme unique to gluconeogenesis?
glucose 6-phosphate
A common intermediate in the conversion of glycerol and lactate to blood glucose is:
pyruvate
In gluconeogenesis, both alanine and lactate are converted in a single step to:
phosphoenolpyruvate
Humans are unable to directly convert pyruvate to:
Pyruvate —> oxaloacetate
Which ONE of the following reactions is unique to gluconeogenesis (not found in glycolysis)?
Glyceraldehyde 3-phosphate + P; —> 1,3-bisphosphoglycerate
Which ONE of the following reactions is shared by glycolysis and gluconeogenesis?
Pyruvate. oxaloacetate
Which ONE of the following groups of compounds is gluconeogenic, that is both intermediates can give rise to the de novo synthesis of blood glucose?