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NME MCQs (II)


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requires the participation of biotin
The synthesis of glucose from pyruvate by gluconeogenesis:
Filtrate of diarrhea fluid in a patient with sucrase deficiency
A negative Clinitest reaction would be expected in which of the following clinical specimens?
glucose 6-phosphatase
A 3-year-old boy had a grossly enlarged abdomen and frequent episodes of weakness and pallor. which ‘ were relieved by eating. He was slightly mentally retarded and of a short height for his age. Bloo
Decreased level of blood triglycerides and free fatty acids released by adipocytes
A 2-year-old girl with stunted growth. a grossly enlarged abdomen, and severe symptoms of mental ‘ retardation had a history of severe hypoglycemic episodes after periods of sleep that extended longer
The only free glucose that can be produced from glycogen in muscle during contraction is provided by the debranching enzyme during glycogen breakdown
Which ONE of the following statements is CORRECT?
Glycogenolysis
Mutations leading to deficiencies in the enzyme phosphoglucomutase might be expected to directly affect which ONE of the following pathways?
Glycogen synthase
In humans. metabolism of glycogen is not a strict on/off process. Gradations of activity in at least one enzyme are documented. Activity of which ONE of the enzymes associated with glycogen metabolism
binding to the alpha-adrenergic receptor and stimulating adenylyl cyclase through the action of a G protein
Epinephrine activates glycogenolysis in the liver by:
Glycogen synthase
Activity of which one of the enzymes associated with glycogen metabolism is modulated by the degree of phosphorylation of the enzyme protein?
In contrast to the case of glycogen stores in liver and muscle. there is no specific mechanism to limit triacylglycerol synthesis in liver or adipose while substrates are abundant
Signaling pathways in the metabolism of glycogen and triacylglycerols have a number of similarities, as well as a few differences. In this regard. which ONE of the following statements is CORRECT‘?
increasing the extent of phosphorylation of glycogen synthase
Glucagon most directly regulates the metabolism of glycogen by:
Both insulin and glucagon signaling can lead to phosphorylation of phosphoprotein phosphatase (also referred to as protein phosphatase 1)
Both insulin and glucagon employ signal transduction pathways in their regulation of the metabolism of glycogen. Which ONE of the following statements regarding this is CORRECT?
Galactose 6-14C
Livers of the same physiologic state were perfused with each one of the radioactive substrates listed. After a short time (<1 hour). the glycogen from each of these livers was isolated. and the 14C di
Muscle glycogen phosphorylase deficiency
A young man comes to you complaining of soreness in his legs and shoulders following moderate to strenuous exercise in his health club's weight room. He shows no signs of hepatomegaly. An overnight
acts by a process that results in the direct release of free glucose
Debranching enzyme:
The only free glucose that can be produced in muscle during contraction is provided by the debranching enzyme during glycogen breakdown
Which ONE of the following statements is CORRECT?
The patient is at risk of lactic acidosis and hyperuricemia as well
A chronically hyperlipidemic and hypoglycemic child has been identified as having a deficiency in glucose 6-phosphatase (type 1 glycogen storage disease). Which statement is correct
Dietary glycogen
Which ONE of the listed substrates will be a good source for blood glucose in an individual with glycogen storage disease type I (glucose 6-phosphatase) disease?
a
q