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Level 29

CVRR 61 - 75 +1


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Kidneys, hepatobiliary system
Routes of drug (and metabolite) excretion. [_______], [_______], lungs and glandular secretions
Lungs and glandular secretions
Routes of drug (and metabolite) excretion. Kidneys, hepatobiliary system, [_______] and [_______]
Drug half-life
Time for plasma concentration to fall to half its initial value of a drug
First order kinetics
Plasma drug levels decline at a rate directly proportional to plasma level
Zero order kinetics
Drug levels decline at a constant linear rate that is independent of plasma concentration
Pharmacodynamics
Mechanisms of drug action and drug-receptor interactions
Agonist
A drug which induces a biological response
Antagonist
A drug which does not induce a biological response
EC50
50% maximum response on a sigmoid dose-response curve
Efficacy
The ability of an agonist to elicit a response following binding to a receptor
Affinity
How easily a drug binds with a receptor
Full agonist
An agonist that elicits a maximum biological response
Partial agonist
An agonist that elicits a partial biological response
Receptor antagonist
An antagonist which binds directly to a receptor
Competitive antagonist
An antagonist which binds to the agonist recognition site and competes with the agonist