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Level 69

CVRR 66 Proximal Tubular Function


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125
The typical male GFR (ml/min)
67%
Percentage of H20 and NaCl reabsorbed in the proximal tubule
100%
Percentage of glucose and amino acid reabsorbed in the proximal tubule
Paracellular and transcellular
The proximal tubule utilises [_______] and [_______] movement to transport substances
Paracellular
Regarding cellular transport, [______] movement is diffusion BETWEEN cells
Transcellular
Regarding cellular transport, [______] movement is diffusion THROUGH cells
Ion gradient, electrical gradient, osmotic gradient
Five modes of movement of substance from the proximal tubule to the plasma. [______], [______], [______], chemical gradient and solvent drag
Chemical gradient and solvent drag
Five modes of movement of substance from the proximal tubule to the plasma. Ion gradient, electrical gradient, osmotic gradient, [______] and [______]
Symporter
The name given to a transport protein that moves two or more substances in the SAME direction
Antiporter
The name given to a transport protein that moves two or more substances in OPPOSITE directions
Reabsorption
Movement of substance from tubule lumen to the blood
Secretion
Movement of substance from blood to the tubule lumen
2
In Proximal tubule, Na+ reabsorption is divided into [__] phases
Glucose, phosphate, amino acid and lactate
By using 4 symporters in the first phase of proximal tubule Na+ reabsorption, virtually all the [____], [____], [____] and [____] is reabsorbed.
Primary active
In the Proximal tubule Na+ is reabsorbed by [________] transport
Secondary active
Na+ acts as a cotransporter for reabsorption of glucose/amino acids by [______] transport
SGLT2
High capacity-low affinity Na-Glu symporter, capable of 90% of glucose absorption
SGLT1
Low capacity-high affinity Na-Glu symporter capable of 10% of glucose absorption
200
If plasma concentration of glucose exceeds the plasma threshold of (___mg/dL) then the SGLT symporters become saturated
Plasma threshold
When glucose exceeds the [_________], it leaves the body with the excretory filtrate (urine)
Water follows glucose
The reason diabetes causes more urination is because [______]