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Level 87

NME Lipid Transport


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Triacylglycerol
TAG
Lipoprotein
Protein lipid particle with hydrophobic core
Chylomicrons
Transport particle of lipids only found in intestine
Very Low Density Lipoprotein
VLDL
Intermediate Density Lipoprotein
IDL
Low Density Lipoprotein
LDL
High Density Lipoprotein
HDL
LDL
[___]s deliver cholesterol to peripheral tissues
HDL
[___]s deliver cholesterol to liver for eliminiation
Free cholesterol
Type of cholesterol used for membranes and precursor
Lipoprotein lipase
Enzyme that is up-regulated by insulin in fed state
Adipose and cardiac
Isomers of lipoprotein lipase
LDL
Major carrier of cholesterol in blood
Apoprotein
Proteins that bind lipids to form lipoproteins
Apoprotein B100
An apoprotein that targets LDL and VLDL
Apoprotein B48
An apoprotein that targets Chylomicrons
Receptor mediated endocytosis
Process by which cells take up LDLs via clathrin coated pits
Familial hypercholesterolemia
A condition characterised by a lack of LDL receptors
HDL
Cholesterol is transported from tissues back to liver (reverse cholesterol transport) by [___]
Gallstones
Excess cholesterol can cause [_____] to form
Liver transplant
Clinical management of Homozygous Familial hypercholesterolemia
Statins
Drug that inhibits cholesterol synthesis
Low and high
HDLs are [high/low] in TAGs and [high/low] in cholesterol
High and low
Chylomicrons are [high/low] in TAG and [high/low] in cholesterol
Chylomicrons
[________] deliver dietary TAG to peripheral tissue
VLDL
[_____]s deliver de novo TAG to peripheral tissue
Synthesised
The meaning of 'de novo' regarding metabolism
Liver and intestine
Major sites of cholesterol synthesis
50%
The % of cholesterol that normally comes from diet
Bile salts and faeces
Methods of cholesterol disposal